Calculation Property of Application Object
ActiveWorkbook.Save
Application.Calculate
Application.Calculation = xlCalculationAutomatic
Sub CalculateData()
ActiveSheet.Range("D2:D6").ClearContents
Application.Calculation = xlCalculationManual
ActiveSheet.Range("D2").Value = "=B2*C2"
ActiveSheet.Range("D2:D6").FillDown
Application.Wait (Now + TimeValue("00:00:05"))
'ActiveWorkbook.Save
Application.Calculate
Application.Calculation = xlCalculationAutomatic
MsgBox "Completed"
End Sub